Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats.
نویسنده
چکیده
The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1--3.5 mg/kg, P2--35.0 mg/kg, P3--350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.
منابع مشابه
Skeletal Malformations in the Holtzman Rat Embryo following the Administration of Thalidomide.
SINCE the occurrence of the thalidomide tragedy in man, fairly extensive animal research has been done on the rat (King & Kendrick, 1962; Bignami et al, 1962; Klein Obbink & Dalderup, 1963; McColl et al, 1963; Moore et al, 1964), mouse (Giroud et al, 1962; Woollam, 1962; DiPaolo, 1963), rabbit (Felisati, 1962; Somers, 1962; Spencer, 1962), monkey (Lucey & Behrman, 1963), chicken (Kemper, 1962; ...
متن کاملMicro-computed tomographic evaluation of fetal skeletal changes induced by all-trans-retinoic acid in rats and rabbits.
BACKGROUND Our laboratory has been conducting positive control studies to evaluate the utility of micro-computed tomography (micro-CT) for qualitative evaluation of fetal skeletal morphology. All-trans-retinoic acid (atRA) was used to produce a different spectrum of defects compared to our previous studies with boric acid and hydroxyurea. METHODS Groups of five mated Crl:CD(SD) female rats ea...
متن کاملEvaluation of Cardiopulmonary Toxicity Following Oral Administration of Multi-walled Carbon Nanotubes in Wistar Rats
Objective(s): Carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. These new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. Up to now, all aspects of carbon nanotubes toxicity are not com...
متن کاملRelationships between fetal body weight of Wistar rats at term and the extent of skeletal ossification.
We investigated the relationship between fetal body weight at term (pregnancy day 21) and the extent of ossification of sternum, metacarpus, metatarsus, phalanges (proximal, medial and distal) of fore- and hindlimbs and cervical and coccygeal vertebrae in Wistar rats. The relationships between fetal body weight and sex, intrauterine position, uterine horn, horn size, and litter size were determ...
متن کاملA Morphometeric Study on CA3 Hippocampal Field in Young Rats Following Maternal Administration of Boswellia Serrata Resin During Gestation
Objective It has previously been shown that prenatal maternal administration of Boswellia serrata gum resin (Frankincense) improved learning and memory performance associated with an increase in the size of neuronal bodies in CA3 (Cornu Ammonis) of hippocampus. Continuing the previous work, a morphometric study was designed on CA3 field to examine precisely the effect of prenatal administratio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Folia morphologica
دوره 59 3 شماره
صفحات -
تاریخ انتشار 2000